RASPBERRY KETONE CLINICAL STUDIES

                                    Raspberry Ketone                                        

Anti-obese action of  Raspberry Ketone

Raspberry Ketone is Generally Recognized As Safe (GRAS) by the FDA. Dr. Chie Morimoto and his colleagues tested to see the effects Raspberry Ketone on mice who were started on a high fat diet, or who had already had obesity induced by a high fat diet. Of the mice who were fed on only a high fat diet for 6 weeks to induce obesity and then the same diet with the introduction of Raspberry
Ketone, their continued weight gain was slowed significantly and there was even some dramatic weight loss at the beginning of taking Raspberry Ketone.

("Anti-obese action of raspberry ketone" Chie Morimotos, Department of Medical Biochemistry. Ehime University School of medicine, Shigenobu-cho, Onsen-gun, Ehime 971-0295, Japan.) 

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Raspberry Ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes

"Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its effects on the expression and the secretion of adiponectin, lipolysis, and fatty acid oxidation in 3T3-L1 were investigated. Treatment with 10µM of RK increased lipolysis significantly in differentiated 3T3-L1 cells. An immunoassay showed that RK increased both the expression and the secretion of adiponectin, an adipocytokine mainly expressed and secreted by adipose tissue. In addition, treatment with 10µM of RK increased the fatty acid oxidation and suppressed lipid accumulation in 3T3-L1 adipocytes. These findings suggest that RK holds great promise as an herbal medicine since its biological activities alter the lipid metabolism in 3T3-L1 adipocytes." Park KS, Nutrition & Functional Food Research Team, Korea Food & Drug Administration, Seoul, Korea
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"The Purpose of this research is to discuss the function mechanism of raspberry ketone on simple obesity and the influence of resistance on obesity relevant insulin. There were 40 SD rats of SPF grade, and the male to female ratio was 1:1. They were randomly divided into 5 groups: NC fed with normal diet. MC fed with high-fat diet. RKL, RKM, and RKH groups fed with high-fat diet and were administered intragastrically with 0.5%, 1%, and 2% of RK for 4 weeks. After 8 weeks, some parameters were tested. The results were processed by statistical analysis. Compared with NC, TG, TC, LDL-C, GLU, INS, IRI, FFA, LEP, TNF-α of MC were significantly increased. Therefore, HDL-C, ISI and APN were significantly decreased. Compared with MC, each parameter in RKL, RKM, and RKH was significantly improved. The results showed that RK have anti-obesity function through combined effects of improving insulin resistance." Wang Lili, Meng Xianjun, Zhang Yan, Zhao Wei. Human Health and Biomedical Engineering (HHBE), 2011 International Conference on, Date of Conference: 19-22 Aug 2011
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                                       African Mangoo                                          

In a breakthrough that could reverse the global obesity epidemic, the natural compound Irvingia Gabonensis – also known as African Mango extract - has been discovered to circumvent the molecular factors involved in obesity.

"More weight loss than any other discovery in supplement history," declared William Faloon, Director of the Life Extension Foundation (a global authority on nutrition, health, and wellness). "For once, the claims that African Mango can cause significant weight loss and even improve blood fat levels, are being supported by some scientific studies," reported the "Diet Doc" Dr. Ingrid van Heerden (registered dietitian and award-winning scientific reporter).

Research on African Mango

The first double-blind research study of Irvingia Gabonensis (African Mangoextract) in humans took place in 2005, comparing participants taking Irvingia Gabonesis to a control group on a placebo. All subjects maintained their normal calorie intake. After 30 days, the participants taking African Mango extract lost an average of 12.3 pounds. On average, subjects taking Irvingia Gabonensis lost 5.3% of their body weight, while the control group only lost 1.3%, which represents a significant difference in weight loss between the two groups. At the same time, the African Mango extract group also exhibited significant reduction in their waist measurements compared to the control group. The study was published in the May 2005 issue of the journal Lipids in Health and Disease. Read the details from the U.S. National Library of Medicine, National Institutes of Health: http://www.ncbi.nlm.nih.gov/pubmed/15916709

                                                                                                                                                            Remarkable results were also found in a second, larger clinical trial of Irvingia Gabonensis (African Mango extract) in 2009. Over a 10-week period, otherwise healthy overweight and obese participants took either Irvingia Gabonesis (150 mg twice daily before meals) or a placebo, while making no other changes to their diet and exercise levels                                                                                                    By the end of the study, those using African Mango extract had lost a significant amount of weight – an average of 28 pounds – while the placebo group lost virtually no weight (~1.5 pounds). The researchers found that the subjects in the African Mango extract group experienced "significant improvements in body weight, body fat, and waist circumference". They had a 13.1% decrease in body weight, shed 6.7 inches from their waistline, and reduced their total body fat by 18.4%. According to the researchers, Irvingia Gabonensis "safely and significantly reduces body weight in overweight and/or obese subjects, and has a favorable impact upon a variety of other metabolic parameters."                                                                                                                                                                                                                                                                                                                   

The researchers also noted that cholesterol levels and blood sugar levels improved significantly compared to the control group. These remarkable blood marker changes reveal specific mechanisms responsible for the profound weight-loss effects observed in participants taking Irvingia Gabonensis. These beneficial changes would also provide considerable protection against diabetes and cardiovascular disease beyond the fat loss benefits.
The study was published in the March 2009 issue of the journal Lipids in Health and Disease. Read the details from the U.S. National Library of Medicine, National Institutes of Health: http://www.ncbi.nlm.nih.gov/pubmed/19254366

This landmark study was so significant it made international news, and was reported by Reuters Health on March 23, 2009. Read their full report online titled "Fruit extract shows promise as weight-loss aid". The study was also featured on FOX News. Check out their March 29, 2009 news story online titled "Exotic Fruit Extract May Shed Pounds, Lower Cholesterol".